Four of the Kings' previous six losses were by one goal; the other two were by two goals.
"We haven't won, but we've played against some good teams and we've played hard," Los Angeles coach Willie Desjardins said. "We've been right in every game. This is the first one we haven't been in."
The Panthers broke the game open with three goals in the final 6:47 of the second period.
Huberdeau gave Florida a 2-1 at 13:33 when he scored on a breakaway after taking a loose puck at center ice after leaving the penalty box.
The puck came to Huberdeau after it rolled around the boards when Anze Kopitar's shot from the right circle went wide of the net.
"That was the difference, I thought, in the game," Panthers coach Bob Boughner said. "I thought for 10 minutes of the second period we weren't very good. We didn't generate a lot. We didn't spend a lot of time in their end. All of a sudden, he gets out of the box and he gets a goal and it's 2-1, and you see the bench automatically stand up a little bit. It was a huge goal in the game."